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Overview

Bioinformatics & Biostatistics Core

General Overview

The Bioinformatics and Biostatistics Core provides comprehensive, high-quality bioinformatics and statistics expertise for Van Andel Institute and external organizations.

The Core develops and maintains automated and customizable workflows for processing and analyzing many types of genomic data; supports the design of rational, robust and reproducible experiments and proposals; assists in the preparation of manuscripts, grants and presentations; and provides education and training in the use of cutting-edge software and analysis methods. The Core can contribute to many types of bioinformatics or statistical projects.

Services include:


Statistical consulting

Experimental design

  • Research proposal development
  • Sample size determination
  • Randomization procedures

Manuscript preparation and data deposition

Genome variant identification, annotation and visualization

Analysis of high-throughput or genome-scale data

  • Bulk and single-cell RNA-Seq and differential gene expression
  • ChIP-Seq, ATAC-Seq, CUT&RUN
  • Spatial molecular profiling
  • Whole Genome Bisulfite Sequencing (WGBS)
  • Metabolomics and lipidomics


Systems-level bioinformatics

  • Gene Over Representation Analysis (ORA)
  • Gene Set Enrichment Analysis (GSEA)
  • Interaction networks
  • Functional enrichment analysis
  • Pathway analysis

Analysis, interpretation, and presentation of data

  • Time-series
  • Tumor growth
  • Drug response

Genome assembly and annotation

Joint analysis of multiple genomic data sets

Custom application and tool development


For more information on services and pricing, please contact Bioinformatics and Biostatistics Core at bbc@vai.org.