BIOINFORMATICS & BIOSTATISTICS CORE

Overview

The Bioinformatics and Biostatistics Core provides comprehensive, high-quality bioinformatics and statistics expertise for Van Andel Institute and external organizations.

The Core develops and maintains automated and customizable workflows for processing and analyzing many types of genomic data; supports the design of rigorous, robust and reproducible experiments and proposals; assists in the preparation of manuscripts, grants and presentations; and provides education and training in the use of cutting-edge software and analysis methods. The Core can contribute to many types of bioinformatics or statistical projects.

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Our Impact

We’re raising thousands to save millions.

We’re turning hope into action for the millions of people around the world affected by diseases like cancer and Parkinson’s. Find out how you can help us make a difference.

141 peer-reviewed papers published in 2025, 74 of which were in high-impact journals
15 VAI-SU2C Epigenetics Dream Team clinical trials launched to date
10 clinical trials and related projects supported by VAI through the International Linked Clinical Trials Program

Support VAI

Services include:

Statistical consulting
Experimental design
- Research proposal development
- Sample size determination
- Randomization procedures
Manuscript preparation and data deposition
Genome variant identification, annotation and visualization
Analysis of high-throughput or genome-scale data
- Bulk and single-cell RNA-Seq and differential gene expression
- ChIP-Seq, ATAC-Seq, CUT&RUN
- Spatial molecular profiling
- Whole Genome Bisulfite Sequencing (WGBS)
- Metabolomics and lipidomics
Systems-level bioinformatics
- Gene Over Representation Analysis (ORA)
- Gene Set Enrichment Analysis (GSEA)
- Interaction networks
- Functional enrichment analysis
- Pathway analysis
Analysis, interpretation and presentation of data
- Time-series
- Tumor growth
- Drug response
Genome assembly and annotation
Joint analysis of multiple genomic data sets
Custom application and tool development

For more information on services and pricing, please contact Bioinformatics and Biostatistics Core at [email protected].

Selected Publications

Authorship & Acknowledgement

All work performed by VAI’s Core Technologies and Services should be acknowledged or considered for co-authorship in scholarly reports, presentations, posters, papers and all other publications. Proper acknowledgment allows us to obtain financial and other support that enables us to provide and maintain high-quality support and services. By acknowledging shared resource facilities and instrumentation in publications, presentations and other research communications, you play a critical role in ensuring their continued availability and future development.

Example acknowledgments:

We thank the Van Andel Institute Bioinformatics and Biostatistics Core (RRID:SCR_024762), especially [staff name], for their assistance with [technique/technology].
This research was supported in part by the Van Andel Institute Bioinformatics and Biostatistics Core (Grand Rapids, MI) (RRID:SCR_024762).

# Equal contributions * Co-corresponding authors